Yes the sexe64 program suggestion by Hiroyuki is simply meant for those who want MinorityClean to run automatically upon Windows starting. I don't understand how much of a difference this might make versus just running it manually, though.
I also have seen his warnings about motherboard or USB DAC being damaged by the program, and he has said similar things about High Grade CPU Any Cures and some of his other programs in the past -- I have yet to have a problem, though, and do not understand under what circumstances one would know if it could damage anything.
Hiroyuki now has four revisions of MinorityClean - I, VI, VII, and VIII -- he says that no one in particular is better, it just depends on your system and you have to try for yourself. So far, after using VII and VIII for some time, I found myself going back to MinorityClean I -- the other two had a noticeable downgrade in SQ. I have not tried VI. MinorityClean I is the only version which restarts its EXE after a certain period of time, maybe that has something to do with it? Unsure.